Skip to main content
padlock icon - secure page this page is secure

The anti-inflammmatory effect of fermented red ginseng in experimental colitic mice

Buy Article:

$63.00 + tax (Refund Policy)

Here we fermented red ginseng (RG, the steamed root of Panax ginseng CA Meyer, Araliaceae) by Bifidobacterium longum H-1 and and investigated whether Bifidus fermentation could increase its anticolitic effect in 2,4,6-trinitrobenzenesulfonic acid- and dextran sulphate sodium (DSS)-induced colitic mice. The colitic mice had shortened colons, decreased body weight, and high myeloperoxidase activity, and administration of RG and fermented RG (FRG) significantly inhibited these changes. These agents also repressed expression of the pro-inflammatory cytokines, IL-1, TNF-α, and cyclooxygenase (COX)-2, as well as the DSS-induced activation of NF-B, with FRG more potently inhibiting the colitic markers than RG. The administration of RG and FRG also significantly reduced the activities of intestinal bacterial -glucuronidase and chondroitin sulphate degradation activities, induced by a colitic inducer. These findings suggest that RG and FRG might improve colitis by regulating inflammatory cytokine expression via NF-B activation, and that the anticolitic effects of RG can be improved by Bifidus fermentation.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: Bifidobacterium longum; colits; fermentation; inflammation; red ginseng

Document Type: Research Article

Affiliations: 1: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea 2: Department of Food and Nutrition, Kyung Hee University, Seoul, Republic of Korea

Publication date: December 1, 2008

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more