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The effects of vitamin A supplementation on the production of hypersensitive inflammatory mediators of ammonia-induced airways of pigs

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Ammonia utilised for various purposes in the field of agriculture is considered one of the most hazardous pollutants, and is known to irritate the airways of farmers and animals. Vitamin A may participate in the modulation of host immune and inflammatory responses. In this study, the beneficial effects of vitamin A supplementation on ammonia-induced pulmonary inflammation and also lung stress due to suboptimal environmental temperature were examined. The results showed that ammonia inhalation significantly increased thromboxane A2 (TXA2) and leukotriene C4 (LTC4) production by the lungs, while vitamin A supplementation significantly reduced the production of TXA2 and LTC4 and it also enhanced prostaglandin I2 (PGI2) in ammonia-induced inflammatory lungs and increased PGI2 production in the lungs of pigs raised at suboptimal environmental temperature. Thus, exposure to ammonia produces a disruptive defect in the lungs and vitamin A supplementation may relieve this detriment by modulating the production of pulmonary inflammatory mediators.
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Keywords: ammonia; eicosanoids; environmental temperature; pig; vitamin A

Document Type: Research Article

Affiliations: 1: Department of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan, ROC,Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan, ROC 2: Department of Animal Science, National Pingtung University of Science and Technology, Pingtung, Taiwan, ROC

Publication date: December 1, 2008

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