Anti-hypersensitive and anti-inflammatory activities of water extract of Zingiber zerumbet (L.) Smith
Crude extracts from traditional herbs have long been used in the treatment of a variety of acute and/or chronic diseases in many countries. Zingiber zerumbet Smith extract has been reported to have anti-inflammatory potential, especially in asthmatic patients. The aim of this study is to examine the capacity of water extract of Zingiber zerumbet (CC-ZWE) in protecting the lungs by inhibiting the release of inflammatory mediators during short-term treatment, and modulating cytokine gene expressions during long-term treatment. BALB/c mice were sensitised and challenged with ovalbumin to induce anaphylaxis. The anti-hypersensitive and anti-inflammatory potentials of water extract of Zingiber zerumbet Smith (ZZ-CWE) were evaluated using both in vitro and in vivo systems. ZZ-CWE decreased the release of tumour necrosis factor-alpha and interleukin-4 (IL-4) in vitro and effectively suppressed LTC4 release from lung tissue in vivo (p<0.05). Additionally, animals treated with ZZ-CWE expressed higher ratios of interferon-gamma/IL-4 mRNA in their splenocytes than that of the control group (p<0.05). Our results showed that ZZ-CWE should have beneficial effects for the treatment of asthmatic patients through its capabilities to inhibit the synthesis of LTC4 and through the immunomodulation of Th1/Th2 cytokine production.
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Zingiber zerumbet Smith;
Document Type: Research Article
Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan, ROC,Department of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan, ROC
Department of Food Science, Rutgers University, New Brunswick, NJ, USA,Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC
Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan, ROC
June 1, 2008
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