This study was undertaken to investigate the effect of 4-arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as a pretreatment
at concentrations ranging from 0.001 to 1 g/kg, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore,
MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-α and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions.
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immediate-type allergic reaction;
tumor necrosis factor-α
Document Type: Research Article
Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand
School of Life Sciences, Xiamen University, Xiamen, China
Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, China
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand
September 1, 2007
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