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4-arylcoumarin inhibits immediate-type allergy

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This study was undertaken to investigate the effect of 4-arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as a pretreatment at concentrations ranging from 0.001 to 1 g/kg, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore, MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-α and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions.
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Keywords: 4-arylcoumarins; immediate-type allergic reaction; interleukin-6; mast cells; tumor necrosis factor-α

Document Type: Research Article

Affiliations: 1: Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand 2: School of Life Sciences, Xiamen University, Xiamen, China 3: Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, China 4: Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand

Publication date: September 1, 2007

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