@article {Xu:2007:0954-0105:83,
title = "The effect of turtle (Trachemys scripta elegans) shell extract in normal and cyclophosphamide-treated mice",
journal = "Food and Agricultural Immunology",
parent_itemid = "infobike://tandf/cfai",
publishercode ="tandf",
year = "2007",
volume = "18",
number = "2",
publication date ="2007-06-01T00:00:00",
pages = "83-93",
itemtype = "ARTICLE",
issn = "0954-0105",
eissn = "1465-3443",
url = "https://www.ingentaconnect.com/content/tandf/cfai/2007/00000018/00000002/art00001",
doi = "doi:10.1080/09540100701327781",
keyword = "immunomodulation, turtle shell extract, Mice, protective function, cyclophosphamide",
author = "Xu, J. H. and Li, A. X. and Zhu, X. Q. and Feng, L. Q. and Xie, M. Q.",
abstract = "In the present study, the immune effect of turtle shell extract on normal and cyclophosphamide (CP)-treated mice was determined. Mice treated with the turtle shell extract and CP had significantly (p<0.05) elevated levels of serum IgG, ATL, ATS and CREA compared with CP-treated mice. The turtle shell extract-treated mice had significantly elevated serum IgG (p<0.001), reduced serum CREA level (p<0.05), but the serum ATL, ATS and BUN did not change significantly compared with normal mice. Treatment with the turtle shell extract significantly improved the CD3+, CD4+CD8-, CD4-CD8+ and CD4+CD8+ cells percentages (p<0.05) in normal mice, and also significantly improved CD3+ and CD4+CD8- cells percentages in CP-treated mice (p<0.05). There was significant difference (p<0.001) in the proliferation rate of PHA-stimulated spleen lymphocyte in vitro between the turtle shell extract + CP-treated mice and CP-treated mice, and also between the turtle shell extract-treated mice and normal mice (p<0.05). These results demonstrate that the turtle shell extract can up-regulate the immune states of normal and CP-treated mice, and shows some protective effect on liver and kidney damage in CP-induced mice.",
}