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Amelioration of late asthmatic bronchial-bronchiolar lesions in BALB/c mice by kurozu moromi powder

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The preventive effect of the development of bronchial-bronchiolar lesions of the late asthmatic response (LAR), a T helper (Th)2 type immune response, in BALB/c mice kurozu moromi powder (kmp) was examined. Mice were pre-treated with or without (control) kmp intra-gastrically for 30 days (50 mg/kg/day) and LAR was induced by ovalbumin (OVA). Compared to the control group, it was recognizable that kmp resulted in reduction of the IgE values and the number of eosinophils, but not lymphocytes, in the blood. Also, the kmp treatment increased significantly in a production of OVA-specific interferon (IFN)-γ from splenic cells. On the other hand, there was no difference in the production of interleukin (IL)-4 and IL-5 between two groups. The control group showed severe bronchial-bronchiolar inflammation, such as goblet cell hyperplasia with prominent mucous secretion, infiltration of eosinophils and lymphocytes, and hypertrophy of smooth muscle in bronchial-bronchiolar walls. These changes were less severe in the mice treated with the kmp. Compared between the two groups, the beneficial effects of kmp were clearly demonstrated and the development of LAR was reduced. This may be due to the activated OVA-specific Th1 cell responses induced by the effects of kmp which leads to the suppression of the development of LAR mediated by Th2 responses.

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Keywords: Asthma; Th2; amelioration; bronchitis; eosinophil; kurozu moromi powder; late asthma

Document Type: Research Article

Affiliations: 1: Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan 2: Laboratory of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, Korimoto, Kagoshima, Japan 3: Sakamoto Brewing Co., Ltd., Kagoshima, Japan

Publication date: September 1, 2006

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