Pathology of clade 2.3.2.1 avian influenza virus (H5N1) infection in quails and ducks in Bangladesh
We performed pathological and molecular virological investigation of three outbreaks of highly pathogenic avian influenza (HPAI) in a quail farm and two duck farms of Mymensingh and Netrokona districts of Bangladesh in 2011. HPAI viruses of subtype H5N1 were detected from all three
outbreaks and phylogenetic analysis of HA gene sequence placed the viruses into clade 2.3.2.1. The outbreak in the quail farm was characterized by acute death with 100% mortality within two days. Marked haemorrhages and congestion with necrotic and inflammatory lesions in the respiratory tract,
liver, pancreas and kidneys were the major gross and histopathological lesions. In the case of ducks, nervous signs were the remarkable clinical manifestations and the mortality was around 10%. No significant gross lesions were observed at necropsy. Non-purulent encephalitis with gliosis and
neuronal degeneration was observed on histopathological examination. By immunohistochemistry, viral antigen could be detected in different organs of both quails and ducks. This study records varying clinical and pathological manifestations of HPAI in ducks and quails following natural infection
with the same strain of the virus.
RESEARCH HIGHLIGHTS
RESEARCH HIGHLIGHTS
HPAIV of clade 2.3.2.1 was detected from clinical outbreaks in quails and ducks
Sudden death with severe haemorrhages in various organs was found in quails
Pronounced nervous signs with non-purulent encephalitis were observed in ducks
Viral antigen could be localized in different organs by immunohistochemistry
Keywords: Bangladesh; HPAI; clade 2.3.2.1; ducks; immunohistochemistry; quails
Document Type: Research Article
Affiliations: Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh
Publication date: 02 January 2019
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