Highly pathogenic avian influenza A/H5N1 Clade 220.127.116.11c virus in poultry in Cameroon, 2016–2017
In May 2016, highly pathogenic avian influenza virus of the subtype A/H5N1 was detected in Cameroon in an industrial poultry farm at Mvog-Betsi, Yaoundé (Centre region), with a recorded sudden increase of deaths among chickens, and an overall mortality rate of 75%. The virus
spread further and caused new outbreaks in some parts of the country. In total, 21 outbreaks were confirmed from May 2016 to March 2017 (six in the Centre, six in the West, eight in the South and one in the Adamaoua regions). This resulted in an estimated total loss of 138,252 birds (44,451
deaths due to infection and 93,801 stamped out). Only domestic birds (chickens, ducks and geese) were affected in farms as well as in poultry markets. The outbreaks occurred in three waves, the first from May to June 2016, the second in September 2016 and the last wave in March 2017. The topology
of the phylogeny based on the haemagglutinin gene segment indicated that the causative H5N1 viruses fall within the genetic clade 18.104.22.168c, within the same group as the A/H5N1 viruses collected in Niger in 2015 and 2016. More importantly, the gene constellation of four representative viruses
showed evidence of H5N1/H9N2 intra-clade reassortment. Additional epidemiological and genetic data from affected countries in West Africa are needed to better trace the origin, spread and evolution of A/H5N1 in Cameroon.
A/H5N1 was detected in May 2016 in domestic chickens in Yaoundé-Cameroon.
Twenty-one outbreaks in total were confirmed from May 2016 to March 2017.
The causative H5N1 viruses fall within the genetic
The viral gene constellation showed evidence of H5N1/H9N2 intra-clade reassortment.
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Document Type: Research Article
Laboratoire National Veterinaire (LANAVET), Yaoundé, Cameroon
Ministry of Livestock, Fisheries and Animal Industries (MINEPIA), Yaoundé, Cameroon
Ministry of Public Health, Yaoundé, Cameroon
FAO-Cameroon, Yaoundé, Cameroon
Centre Pasteur of Cameroon, Yaoundé, Cameroon
Metabiota Cameroon, Yaoundé, Cameroon
CRESAR, Yaoundé, Cameroon
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy
Emerging and Reemerging Zoonotic Diseases Program, Yaoundé, Cameroon
Food and Agriculture Organization of the United Nations (UN-FAO) Headquarters, Roma, Italy
UN-FAO Regional Office, Ghana & Gabon
USAID Preparedness and Response Project, Accra, Ghana
Administration, University of Bamenda, Bamenda, Cameroon
Biotechnology Centre, University of Yaoundé I, Yaoundé, Cameroon
Animal Production and Health Laboratory, Joint FAO/IAEA Division for Nuclear Applications in Food and Agriculture, IAEA, Vienna, Austria
Publication date: November 2, 2018
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