A turkey rhinotracheitis outbreak caused by the environmental spread of a vaccine-derived avian metapneumovirus
Avian metapneumovirus (aMPV) subtype A was isolated from 7-week-old turkeys showing respiratory disease typical of turkey rhinotracheitis. Comparison of the virus sequence with previously determined vaccine marker sequences showed that the virulent virus had originated from a licensed
live subtype A aMPV vaccine. The vaccine had neither been in use on the farm within a period of at least 6 months nor had it been used on farms within a distance of approximately 5 km. Isolation of the virus and exposure to naive turkeys caused disease typical of a virulent aMPV field strain.
The study shows that disease was caused by exposure to aMPV vaccine-derived virus that was present in the environment, and indicates that such virus is able to circulate for longer than was previously envisaged.
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Document Type: Research Article
Dipartimento di Scienze Mediche Veterinarie,Alma Mater Studiorum—University of Bologna, Via Tolara di Sopra 5040064Ozzano EmiliaBO, Italy
Dipartimento di Sanità Pubblica, Patologia Comparata e Igiene Veterinaria,Faculty of Veterinary Medicine, University of Padua, Viale dell'Università 1635020LegnaroPD, Italy
Department of Infection Biology, Institute of Infection and Global Health,Faculty of Health and Life Sciences, Leahurst Campus, University of Liverpool, LiverpoolCH64 7TE, UK
Publication date: October 1, 2011
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