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Open Access Quantitative comparison of intestinal invasion of zoonotic serotypes of Salmonella enterica in poultry

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The aim of the present study was to compare the invasion of selected zoonotic Salmonella serotypes of poultry in an in vivo chicken intestinal loop model and also in vitro in epithelial cell cultures. Invasion was measured relative to a reference strain, Salmonella Typhimurium 4/74 invH201::TnphoA. Two serotypes demonstrated intracellular log10 counts that differed significantly from all other serotypes tested: Salmonella Enteritidis PT4 being 1.5 log10 colony forming units (CFU) (31-fold) higher, and Salmonella Tennessee being 0.7 log10 CFU (fivefold) lower than the reference strain (P ≤ 0.0001). A group of serotypes, which can be vertically transmitted, showed significantly higher intracellular counts (fourfold to eightfold) than the reference strain. The group included S. Typhimurium 4/74, S. Typhimurium DT104 (poultry and porcine isolates), S. Enteritidis PT1, S. Enteritidis PT6, S. Enteritidis PT8, and Salmonella Berta. The serotypes Salmonella Hadar, Salmonella Virchow, S. 4,12:b:-, S. Typhimurium DT41, and Salmonella Infantis, most of which are considered horizontally transmitted, did not show significantly different intracellular counts from the reference strain. Results from the cell culture invasion studies agreed with the in vivo data, with the exception of S. Berta and the poultry isolate of S. Typhimurium DT104.

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Document Type: Original Article

Affiliations: 1: Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark; [email protected] 2: Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark 3: The Danish Veterinary Laboratory, København V, Denmark

Publication date: February 1, 2002

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