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Open Access Pigeon circovirus infection: pathological observations and suggested pathogenesis

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Pigeon circovirus infection (PiCV) was diagnosed by light and transmission electron microscopy in 15 birds from five lofts in western France. Histopathological findings were suggestive of primary bursotropism of pigeon circovirus, followed by secondary systemic spread from the bursa of Fabricius, particularly to non-bursal lymphoid organs. The last stage of the disease was associated with various secondary (particularly bacterial) infections. In situ detection of apoptosis in the bursa of Fabricius indicated that PiCV was concomitant with an increase in bursal lymphocytic apoptotic events related to viral infection and leading to severe acquired immunosuppression.

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Document Type: Original Article

Affiliations: 1: Department of Pathology, Veterinary School, Atlanpole la Chantrerie, BP 40706, 44307 Nantes cedex, France 2: Laboratoire de Développement et d'Analyses 22, 7 rue du Sabot, BP 54, 22440 Ploufragan, France, France 3: TECHNA, Les Landes de Bauche, BP 10, 44200 Couëron, France 4: Veterinary Centre, 11 rue des Buttes, 56230 Questembert, France

Publication date: April 1, 2001

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