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Free Content Beyond the Discovery Void: New targets for antibacterial compounds

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Antibiotics save many lives, but their efficacy is under threat: overprescription, population growth, and global travel all contribute to the rapid origination and spread of resistant strains. Exacerbating this threat is the fact that no new major classes of antibiotics have been discovered in the last 30 years: this is the "discovery void." We discuss the traditional molecular targets of antibiotics as well as putative novel targets.

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Keywords: ANTIBIOTICS; BACTERIAL RESISTANCES TO ANTIBIOTICS; CELL DIVISION; CELL WALL; DISCOVERY VOID; MRSA

Document Type: Review Article

Affiliations: University of Warwick

Publication date: June 1, 2016

This article was made available online on June 8, 2016 as a Fast Track article with title: "Beyond the Discovery Void: New targets for antibacterial compounds".

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  • Science Reviews 2000 is pleased to announce that Science Progress has been acquired by SAGE Publishing as of 7th December 2018. For more information, please visit https://uk.sagepub.com/en-gb/eur/sciencereviews2000

    SCIENCE PROGRESS has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field. Science Progress commissions world authorities to contribute articles on the most interesting, important and meaningful topics - ranging from cosmology to the environment - and ensures that they are presented for the most effective use of those in both academia and industry.

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    Cover image: Plastic debris washed-up on a river bank. The manufacture and use of different types of plastic, and the effects of pollution by these materials are discussed in the article on pages 207?260. Credit: By igorstevanovic/Shutterstock.com.

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