Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Dollings, Melissa C.
AU - Brown, Lisa
TI - An Integrated Review of Intestinal Microbiota in the Very Premature Infant
JO - Neonatal Network
PY - 2016-07-01T00:00:00///
VL - 35
IS - 4
SP - 204
EP - 216
KW - LATE-ONSET SEPSIS
KW - GASTROINTESTINAL
KW - MICROBIOTA
KW - NECROTIZING ENTEROCOLITIS
KW - PREMATURE INFANT
N2 -
Background: The intestinal microbiota is important for optimal intestinal function and protection against infection. Disruption of the intestinal microbiota has been linked to necrotizing enterocolitis (NEC) and late-onset sepsis (LOS).
Objectives: To determine what
is known about the intestinal microbiota of very premature infants. We describe the relationship of the intestinal microbiota to NEC and LOS and provide an overview of the effect of environmental factors.
Methods: A review was conducted using PubMed/MEDLINE from 2008 to 2015 to
examine what is currently known about the intestinal microbiota of very premature infants.
Discussion: The intestinal bacteria are low in diversity and generally contain a predominance of potentially pathogenic bacteria. Evidence suggests that these bacteria play a role in NEC as
well as LOS through translocation. Environmental factors such as mode of delivery, use of antibiotics, and type of feeding may also contribute to the development of the intestinal microbiota.
UR - https://www.ingentaconnect.com/content/springer/jnn/2016/00000035/00000004/art00005
M3 - doi:10.1891/0730-0832.35.4.204
UR - https://doi.org/10.1891/0730-0832.35.4.204
ER -