Human chorionic gonadotropin as a target for cancer vaccines.
Human chorionic gonadotropin (hCG) is expressed by common cancers and may play a role in cell transformation as well as angiogenic, metastatic, and immune escape phenomena that are central to cancer progression. Clinical trials with a vaccine targeting the carboxy-terminal peptide of -hCG have indicated that tolerance to this oncofetal antigen can be broken. Humoral responses that may modulate the biologic activity of tumor-associated hCG as well as cellular responses to hCG have been generated. Studies are in progress to further define the biologic significance of hCG in cancer and to develop a vaccine approach that will best target this expression.
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Document Type: Research Article
Affiliations: The Ohio State University Comprehensive Cancer Center, The Arthur G. James Cancer Hospital and Research Institute, Columbus, OH 43210, USA.
Publication date: January 1, 1999
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