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Expression of Hippo pathway genes and their clinical significance in colon adenocarcinoma

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Yes-associated protein 1 (YAP1) is a transcriptional regulator of the Hippo pathway, which regulates the development and progression of a number of types of cancer, including that of the colon. In the present study, the expression levels of Hippo pathway genes and their clinical significance were investigated in 458 patients with colon adenocarcinoma (COAD), the most frequently diagnosed neoplastic disease globally, using data obtained from The Cancer Genome Atlas database. Notably, mRNA expression of YAP1 was higher in COAD than in other types of gastrointestinal tract cancer. Expression of YAP1 mRNA was higher in COAD than in normal colon samples and was significantly higher in TumorNodeMetastasis (TNM) stages IIIIV than in stages III. YAP1 protein levels, a protein primarily localized in the nucleus, was greater in TNM stages IIIIV than in stages III. The level of pYAP1, which is inactive and localized in the cytoplasm, was significantly higher in TNM stages IIIIV than in stages III. However, the YAP1/pYAP1 ratio, which is representative of activity, was higher in TNM stages IIIIV than in stages III. High mRNA expression of YAP1, TAZ and TEAD4 was associated with a poor prognosis in patients with COAD. Bioinformatics analysis revealed that YAP1 was associated with DNA duplication, cell proliferation and development. Wnt signaling and transforming growth factorβ signaling were significantly higher in the highYAP1 group, according to data from Gene Set Enrichment Analysis. Taken together, the results indicate that the subcellular distribution of YAP1 and high mRNA expression of YAP1, TAZ and TEAD4 may be associated with poorer overall survival rates in patients with COAD.
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Document Type: Research Article

Affiliations: 1: Department of Surgery, School of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea 2: Clinical Research Department, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea 3: Department of Anatomy, Seoul National University, College of Medicine, Seoul 03080, Republic of Korea

Publication date: April 1, 2018

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  • Oncology Letters is a monthly, peer-reviewed journal, available in print and online, that focuses on all aspects of clinical oncology, as well as in vitro and in vivo experimental model systems relevant to the mechanisms of disease.

    The principal aim of Oncology Letters is to provide the prompt publication of original studies of high quality that pertain to clinical oncology, chemotherapy, oncogenes, carcinogenesis, metastasis, epidemiology and viral oncology in the form of original research, reviews and case reports.
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