Cyclooxygenase2 (COX2) and interleukin32 (IL32) expression has been examined in various carcinomas and inflammations, and has been suggested to be significant in tumor progression and prognosis. The present study was conducted to investigate the expression of COX2 and IL32 in primary
gastric Bcell lymphoma in order to define their clinical significance and their association with Helicobacter pylori (Hp) infection. COX2 and IL32 protein expression was detected in 31 primary gastric Bcell lymphoma patients and 19 chronic gastritis patients with immunohistochemistry.
COX2 and IL32 expression was significantly higher in primary gastric lymphoma (PGL) tissues compared with gastritis tissues (51.6 vs. 21.1% for COX2, P=0.032; and 58.1 vs. 26.3% for IL32, P=0.029) and was significantly higher in Hp+ lymphoma tissues compared with Hp lymphoma
tissues (66.7 vs. 20% for COX2, P=0.015; and 71.4 vs. 30% for IL32, P=0.029). In the PGL tissues, the expression level of COX2 was positively correlated with the expression level of IL32, and the two were each positively correlated with Hp infection (P=0.004 for COX2 and
IL32; P=0.01 for COX2 and Hp infection; and P=0.003 for IL32 and Hp infection). COX2 expression was found to be significantly associated (P<0.05) with an aggressive tumor type, higher expression of Ki67, frequent lymph node metastasis and advanced stage. IL32 expression was found to be
significantly correlated (P<0.05) with frequent lymph node metastasis and an advanced stage. The survival time was longer in the COX2 and IL32 lymphoma patients compared with the COX2+ and IL32+ lymphoma patients, but these differences were not statistically significant. These
results suggested that Hp infection and the expression of COX2 and IL32 were closely linked with each other, and that the overexpression of COX2 and IL32 was correlated with tumor progression in primary gastric Bcell lymphoma, thus indicating potential novel therapeutic target.
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Document Type: Research Article
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, P.R. China
Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Publication date: January 1, 2016
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Oncology Letters is a monthly, peer-reviewed journal, available in print and online, that focuses on all aspects of clinical oncology, as well as in vitro and in vivo experimental model systems relevant to the mechanisms of disease.
The principal aim of Oncology Letters is to provide the prompt publication of original studies of high quality that pertain to clinical oncology, chemotherapy, oncogenes, carcinogenesis, metastasis, epidemiology and viral oncology in the form of original research, reviews and case reports.
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