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Involvement of gut microbiota in the association between gastrointestinal motility and 5HT expression/M2 macrophage abundance in the gastrointestinal tract

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Serotonin (5hydroxytryptamine; 5HT) may be a key player in gastrointestinal (GI) motility and the GI immune system. In the present study, the effect of gut microbiota on the association between GI motility, and 5HT expression and macrophage abundance in the GI tract was examined. Germfree (GF) mice (6 weeks old) were orally administered a fecal bacterial suspension prepared from specific pathogenfree mice and their GI tissues were evaluated 4 weeks later. The expression of 5HT and mannose receptor (MR) was examined by immunohistochemistry, and GI transit time (GITT) was measured by administration of carmine red solution. The numbers of 5HTpositive endocrine cells and muscularis MRpositive macrophages were significantly increased in the upper GI and colon of GF mice subjected to fecal transplantation (FT) compared with control GF mice without FT. GITT was significantly decreased in GF mice subjected to FT compared with GF mice without FT, and negatively correlated with the numbers of 5HTpositive cells in the upper GI and muscularis MRpositive macrophages throughout the GI tract. The numbers of 5HTpositive endocrine cells and muscularis MRpositive macrophages were significantly correlated throughout the GI tract. The present results suggest that the gut microbiota is involved in the association between accelerated GI motility and induction of the 5HT/muscularis MRpositive macrophage axis in the GI tract.
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Document Type: Research Article

Affiliations: Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 6638501, Japan

Publication date: September 1, 2017

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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