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Identification of microRNAs in acute respiratory distress syndrome based on microRNA expression profile in rats

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Acute respiratory distress syndrome (ARDS) remains a severe disease associated with an ~40% mortality rate and as many as 200,000 new cases annually. MicroRNAs (miRNAs) have important roles in gene regulation and cancer development. The present study aimed to identify the potential roles of miRNAs in the pathogenesis and progression of ARDS. The miRNA expression profile of the GSE57223 dataset was downloaded from the Gene Expression Omnibus database. Following data normalization, differentially expressed miRNAs were identified using the ttest method. The miRWalk database was searched to predict target genes of the identified miRNAs and then a miRNAmiRNA network with coregulated target genes was constructed. Additionally, Gene Ontology (GO) analysis was performed for the target genes and a miRNAmiRNA functional synergistic network (MFSN) was established. GO and pathway analyses were performed for the coregulated target genes of significant miRNAs in MFSN. Additionally, a proteinproteininteraction network was constructed for these target genes. A total of 19 miRNAs were differentially expressed between ARDS and normal lung tissue were identified. The four downregulated rnolet7 family members were detected to have numerous coregulated target genes and synergistic functions. Additionally, the target genes of the four miRNAs were significantly enriched the biological processes of wounding and inflammatory response. Additionally, interleukin (IL)6 was identified as a hub protein with a high degree. The four downregulated rnolet7 miRNAs may be involved in the inflammatory process in the pathogenesis and progression of ARDS, via the synergistic regulation of their target genes, such as IL6. However, additional experimental validation is required.
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Document Type: Research Article

Affiliations: 1: Department of Respiratory Medicine, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China 2: Intensive Care Unit, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China

Publication date: September 1, 2017

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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