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The role of intestinal endotoxemia in a rat model of aluminum neurotoxicity

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The present study aimed to investigate the effects of intestinal endotoxemia (IETM) in a rat model of aluminum neurotoxicity established by D-galactose and aluminum trichloride (AlCl3). Adult Wistar rats were administered Dgalactose and AlCl3 to create the aluminum neurotoxicity model. The learning and memory abilities of the rats were subsequently observed using a Morris water maze test and the serum levels of lipopolysaccharide (LPS), tumor necrosis factor (TNF)α, interleukin (IL)1, diamine oxidase (DAO), glutamine (Gln) and glutaminase were measured. The expression of S100β in the serum was detected using an enzymelinked immunosorbent assay. The expression levels of the amyloid βprotein (Aβ) precursor (APP), presenilin 1 (PS1), βsite APPcleaving enzyme (BACE), zona occludens protein (ZO)1 and Aβ 140 in the brain of rats were detected via reversetranscription polymerase chain reaction, western blotting and immunohistochemistry. The levels of LPS, TNFα, IL1, DAO, Gln and S100β in serum and the mRNA and protein expression levels of APP, PS1, BACE and Aβ140 in the brain were markedly increased in the model rats compared with controls. The level of glutaminase in the serum and the expression of ZO1 in the brain were decreased in the model rats compared with controls. IETM was present in the rat model of aluminum neurotoxicity established by Dgalactose and AlCl3 and may be important in the development of this neurotoxicity.
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Document Type: Research Article

Affiliations: 1: Department of Pathophysiology, Key Laboratory of Cell Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China 2: Department of Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030013, P.R. China 3: Department of Biochemistry and Molecular Biology, Key Laboratory of Cell Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China 4: Department of Psychiatry, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China 5: The Experimental Center of Science and Research, The First Hospital, Institute of Hepatopathy, Key Laboratory of Cell Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China

Publication date: August 1, 2017

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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