Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristineinduced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established
in SpragueDawley rats by intraperitoneal injection of vincristine sulfate 50 µg/kg once a day for 10 consecutive days. Fucoidan (50, 100 or 200 mg/kg.) and pregabalin (10 mg/kg) were injected for 14 consecutive days. Behavioral assessments were then performed and
the expression of GABAB receptor was determined. The results showed that a single treatment with fucoidan did not prevent the induction of vincristineinduced mechanical or cold allodynia. However, repeated fucoidan administration attenuated vincristineinduced mechanical and cold allodynia
in a dosedependent manner. Additionally, the analgesic effects of fucoidan contributed to an upregulation in the expression of GABAB receptor in the spinal cord. Furthermore, all the effects of fucoidan against vincristineinduced neuropathy were reversed by saclofen, a selective GABAB receptor
antagonist. These results suggested that the antinociceptive effects of fucoidan may be through activation of GABAB receptor, and fucoidan may be a promising drug for the treatment of chemotherapeutic drug-induced neuropathic pain.
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Document Type: Research Article
Department of Biology, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China
Modern Biochemistry Center, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P.R. China
Department of Physiology, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China
Publication date: January 1, 2017
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Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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