MicroRNA216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B
There is increasing evidence to suggest that microRNAs (miRNAs; miRs) are involved in the development of oral squamous cell carcinoma (OSCC). miR216a has been identified as being involved in tumorigenesis, however, the mechanisms of miR216a in various types of cancer, either as a tumor suppressor or as an oncogenic miRNA, and the specific regulatory role of miR216a in OSCC remain to be elucidated. The present study demonstrated that the expression of miR216a was significantly reduced in OSCC tissues and cell lines. Overexpression of miR216a significantly suppressed the proliferation, colony formation, migration and invasion of the OSCC cells. In addition, eukaryotic translation initiation factor 4B (EIF4B) was identified as a direct target of miR216a, which was observed to be upregulated in the OSCC tissues. Furthermore, overexpression of EIF4B significantly attenuated the antitumor effect of miR216a, and a negative correlation was observed between miR216a and EIF4B in the OSCC tissues. Taken together, these findings indicated that miR216a has a suppressive role in OSCC cells by directly targeting EIF4B, and may function as a potential prognostic biomarker and novel therapeutic target.
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Document Type: Research Article
Affiliations: Department of Stomatology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
Publication date: August 1, 2015
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