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Quercetin induces the apoptosis of human ovarian carcinoma cells by upregulating the expression of microRNA145

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Ovarian cancer is one of the most malignant types of cancer of the female human reproductive track, posing a severe threat to the health of the female population. Numerous previous studies have demonstrated that microRNA (miR)145 is downregulated in ovarian cancer, and that quercetin can inhibit the growth of cancer cells via regulating the expression of miRs. Therefore, the present study investigated the effect of quercetin on the expression of miR145 in SKOV3 and A2780 human ovarian cancer cell lines. The results revealed that the expression levels of cleaved caspase3 in the SKOV3 and A2780 cells were significantly increased following treatment to induce overexpression of miR145 compared with treatment with quercetin alone (P<0.01). However, the expression of cleaved caspase3 in the antimiR145 (miR145 inhibitor) group of cells was markedly decreased compared with that in the miR145 overexpression groupĀ (P<0.01). Taken together, the results suggested that treatment with quercetin induced the apoptosis of human ovarian carcinoma cells through activation of the extrinsic death receptor mediated and intrinsic mitochondrial apoptotic pathways.
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Document Type: Research Article

Affiliations: 1: College of Life Sciences, Huzhou Teachers College, Huzhou, Zhejiang 313000, P.R. China 2: College of Fisheries, Henan Normal University, Xinxiang, Henan 453007, P.R. China 3: Department of Gynaecology, The Medical Group of Zhengzhou First People's Hospital, Zhengzhou, Henan 450004, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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