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MicroRNA29a inhibits cell migration and invasion by targeting Roundabout 1 in breast cancer cells

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MicroRNAs (miRs) are a group of small noncoding RNAs, which influence the development and progression of cancer by mediating the protein expression levels of tumor suppressors or oncogenes. miR29a has been reported to be involved in the pathogenesis of breast cancer. However, its precise functions, and the mechanisms underlying these effects, remain to be elucidated. The present study demonstrated that miR29a was markedly downregulated in breast cancer tissues and cell lines. The protein expression of Roundabout 1 (Robo1) was negatively regulated by miR29a in MCF7 breast cancer cells. Luciferase reporter assays identified Robo1 as a direct target of miR29a in MCF7 cells. Additionally, upregulation of miR29a inhibited MCF7 cell migration and invasion, which was attenuated by the restoration of the expression of Robo1. Finally, it was shown that the expression of Robo1 mRNA and protein was increased in breast cancer tissues and cell lines. Therefore, it was hypothesized that miR29a inhibits cell migration and invasion in breast cancer cells, at least in part, by directly targeting Robo1. In conclusion, the present study highlights the importance of miR29a and Robo1 in the progression of breast cancer.
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Document Type: Research Article

Affiliations: 1: Department of Microbiology and Immunology, Medical School of Jishou University, Jishou, Hunan 416000, P.R. China 2: Institute of Medical Research, Medical School of Jishou University, Jishou, Hunan 416000, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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