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MicroRNA137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo

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Epithelial ovarian cancer (EOC) remains a major gynecological problem, with a poor 5yearsurvival rate due to distant metastases. The identification of microRNAs (miRNAs) may provide a novel avenue for diagnostic and treatment regimens for EOC. Several miRNAs have been reported to be involved in the progression of EOC, among which miRNA (miR)137 has been observed to be downregulated in the ovarian tissues of patients with EOC. However, the functions of miR137 in EOC cell apoptosis, migration and invasion remain to be elucidated. In the present study, the expression of miR137 was measured in clinical ovarian cancer specimens and cell lines using reverse transcriptionquantitative polymerase chain reaction. The role of miR137 in the growth and survival of the SKOV3 human ovarian cancer cell line was determined using several in vitro approaches and in nude mouse models. The results demonstrated that the expression of miR137 was downregulated in the ovarian cancer specimens and cell lines. It was also observed that enforced expression of miR137 in the EOC cell lines decreased cell proliferation, clonogenicity, migration and invasion, and induced G1 arrest and cell apoptosis in vitro. Notably, the enforced expression of miR137 suppressed tumor growth in the nude mice models. These findings suggested that miR137 may act as a tumor suppressor and be used as a potential therapeutic agent for the treatment of EOC.
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Document Type: Research Article

Affiliations: 1: Department of Obstetrics and Gynecology, The Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China 2: Department of Infectious Diseases, The Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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