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Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma

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MicroRNA (miR)-510-5p has been demonstrated to be involved in a number of types of malignancy; however, the function of miR5105p in renal cancer remains unclear. The present study aimed to determine the expression of miR5105p in renal cell carcinoma (RCC) specimens and analyzed the impact of miR5105p on renal cancer by 3-(4,5dimethylthiazol2yl)2,5diphenyltetrazolium bromide, wound scratch and apoptosis assays. The results showed that miR5105p was significantly downregulated in RCC specimens compared with normal renal specimens. Overexpression of miR5105p by synthetic mature mimics reduced cell proliferation and migration and induced an increase in cell apoptosis, indicating that miR5105p may act as a tumor suppressor in RCC. The present study firstly revealed that downregulated miR5105p functioned as a tumor suppressor by reducing cellular proliferation and migration, and inducing apoptosis in RCC. Further research is required to define target genes of miR5105p to determine the cellular mechanism of miR5105p in the carcinogenesis of RCC.
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Document Type: Research Article

Affiliations: 1: Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China 2: The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology of Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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