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Detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: Exacerbation versus stable condition

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Latent infection with adenovirus and respiratory syncytial virus (RSV) is associated with chronic obstructive pulmonary disease (COPD). The role of respiratory viral infections are emerging in COPD exacerbations. The present study aimed to investigate the prevalence of adenovirus and RSV serotypes A and B in individuals with acute exacerbations of COPD (COPDAE) and stable COPD. Twenty seven patients with COPDAE were evaluated using a prospective longitudinal study design. Induced sputum, sera and nasal smears were sampled from patients experiencing COPDAE and those in a stable condition. Adenoplex® multiplex polymerase chain reaction (PCR) kits and Invitek RTP® DNA/RNA Virus Mini kits were used for PCR assays of adenovirus and RSV, respectively. Eighteen patients who experienced a COPDAE were also evaluated while in a stable condition. The results showed that three sputum samples were positive for adenovirus in patients experiencing an exacerbation, while one was positive among the patients in a stable condition. RSV serotype A was detected in 17/27 (63%) patients with COPDAE and 10/18 (55.6%) patients in a stable condition. RSV serotype B was not detected. Patients with COPDAE, who were positive for RSV serotype A exhibited higher serum fibrinogen levels than those who were negative (438.60±126.08 mg/dl compared with 287.60±85.91 mg/dl; P=0.004). Eight/ten patients who were positive for RSV serotype A while in a stable condition, were also positive during COPDAE. The results of the present study suggested that RSV infection may be prevalent in patients with COPDAE and in those in a stable condition. Therefore, chronic RSV infection may occur in COPD. The detection and prevention of RSV may be useful in the management of COPD.
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Document Type: Research Article

Affiliations: 1: Department of Pulmonary Medicine, Gazi University Faculty of Medicine, Ankara 06510, Turkey 2: Department of Clinical Microbiology, Gazi University Faculty of Medicine, Ankara 06510, Turkey 3: Department of Clinical Microbiology, Alanya State Hospital, Antalya 07400, Turkey 4: Department of Biochemistry, Gazi University Faculty of Medicine, Ankara 06510, Turkey

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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