Protective effects of gallic acid against spinal cord injuryinduced oxidative stress
The present study aimed to investigate the role of gallic acid in oxidative stress induced during spinal cord injury (SCI). In order to measure oxidative stress, the levels of lipid peroxide, protein carbonyl, reactive oxygen species and nitrates/nitrites were determined. In addition, the antioxidant status during SCI injury and the protective role of gallic acid were investigated by determining glutathione levels as well as the activities of catalase, superoxide dismutase, glutathione peroxidase and glutathioneStransferase. Adenosine triphophatase (ATPase) enzyme activities were determined to evaluate the role of gallic acid in SCIinduced deregulation of the activity of enzymes involved in ion homeostasis. The levels of inflammatory markers such as nuclear factor (NF)κB and cycloxygenase (COX)2 were determined by western blot analysis. Treatment with gallic acid was observed to significantly mitigate SCIinduced oxidative stress and the inflammatory response by reducing the oxidative stress, decreasing the expression of NFκB and COX2 as well as increasing the antioxidant status of cells. In addition, gallic acid modulated the activity of ATPase enzymes. Thus the present study indicated that gallic acid may have a role as a potent antioxidant and antiinflammatory agent against SCI.
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Document Type: Research Article
Affiliations: Department of Orthopedics, The 117th Hospital of People's Liberation Army, Hangzhou, Zhejiang 310013, P.R. China
Publication date: August 1, 2015
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- Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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