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Upregulation of GRIM19 inhibits the growth and invasion of human breast cancer cells

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Gene associated with retinoidinterferon (IFN)induced mortality¬†19 (GRIM19), a novel IFNβ/retinoic acidinducible gene product, has been identified as a potential tumor suppressor, which is associated with the inhibition of tumor growth. GRIM19 has been demonstrated to be downregulated in the ovarian tissue of patients with breast cancer, however, its role in breast cancer remains to be fully elucidated. In the present study, a recombinant eukaryotic expression plasmid carrying GRIM19 was constructed and then transfected into the MCF7 human breast cancer cell line to examine its effects on breast cancer cell growth, migration and invasion using several in¬†vitro approaches. The results demonstrated that upregulation GRIM19 in the MCF7 cells significantly inhibited cell proliferation, colony formation, migration and invasion, and induced cell apoptosis. Additionally, upregulation of GRIM19 also suppressed the secretion of urokinasetype plasminogen activator (uPA), matrix metalloproteinase (MMP)2, MMP9 and vascular endothelial growth factor (VEGF). It was also demonstrated that the activation of signal transducer and activator of transcription¬†3 (STAT3) was downregulated by the expression of GRIM19. These results revealed that overexpression of the GRIM19 gene may be an effective approach to control the growth and invasion of human breast cancer cells.
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Document Type: Research Article

Affiliations: 1: Department of Cosmetology Plastic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China 2: Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China 3: Department of Neurological Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China 4: Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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