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Calponinh2 is upregulated in the tissues and plasma of patients with breast cancer

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Increasing evidence has demonstrated that changes in plasma nuclear matrix proteins are specific markers of cancer. Furthermore, proteomic analysis has revealed that calponinh2 is upregulated in human breast cancer tissue, but is absent in healthy and benign controls. However, the roles of levels of plasma calponinh2 in the diagnosis of breast cancer and its association with clinicopathological parameters remain to be elucidated. In the present study, the plasma levels of calponinh2 in patients with breast cancer, benign breast disease and in healthy controls were examined using an enzymelinked immunosorbent assay. The expression levels of calponinh2 in invasive breast cancer and normal breast tissues were measured using immunohistochemistry. Statistical analyses examined the association between the levels of plasma calponinh2 and clinicopathological parameters. The results demonstrated that the plasma level of calponinh2 in breast cancer was significantly higher than those in the healthy control and benign breast disease groups (P<0.05). The combination of calponinh2, carcinoembryonic antigen, carbohydrate antigen 153 improved the diagnosis of breast cancer. The plasma levels of calponinh2 PR breast cancers was significantly higher, compared with PR+ breast cancers (P=0.033), and the plasma levels of calponinh2 in patients with breast cancer aged >50¬†years was significantly higher than in patients ≤50¬†years of age (P=0.001). No association was found between the level of plasma calponinh2 and other clinicopathological parameters of breast cancer. Taken together, these results indicated that calponinh2 may be a useful marker of breast cancer.
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Document Type: Research Article

Affiliations: 1: Department of Clinical Laboratory, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China 2: Department of VIP Obstetrics, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China 3: Department of Pathology, Guangdong Women and Children Hospital, Guangzhou, Guangdong 511442, P.R. China 4: Department of Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510140, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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