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Pachymic acid protects H9c2 cardiomyocytes from lipopolysaccharide-induced inflammation and apoptosis by inhibiting the extracellular signal-regulated kinase 1/2 and p38 pathways

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Pachymic acid (PA), a lanostane-type triterpenoid and the major component of Poria cocos alcoholic extracts, has various pharmacological effects, including antiinflammatory, antioxidative and antiapoptotic. However, few studies have investigated the effects of PA on lipopolysaccharide (LPS)induced H9c2 cell apoptosis and inflammation, or identified the possible mechanisms underlying these effects. In the present study, H9c2 cardiomyocytes were stimulated by LPS and treated with or without PA. The increased mRNA expression levels of tumor necrosis factorα, interleukin (IL)1 and IL6 induced by LPS were attenuated following treatment with PA. PA also attenuated LPSinduced apoptosis, as determined by a terminal deoxynucleotidyl transferase dUTP nick end labeling assay, and regulated the LPSinduced protein expression levels of caspase 3, 8 and 9. Furthermore, the phosphorylations of extracellularregulated kinase (Erk)1/2 and p38 in the LPStreated H9c2 cells were inhibited by PA. These results suggested that treatment with PA prevented the LPSinduced inflammatory and apoptotic response in cardiomyocytes, which may be mediated by inhibition of the Erk1/2 and p38 pathways.
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Document Type: Research Article

Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hebei 430060, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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