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Paeoniflorin inhibits proliferation and induces apoptosis of human glioma cells via microRNA-16 upregulation and matrix metalloproteinase-9 downregulation

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Paeoniflorin is one of the active ingredients of the commonly used herbal medicine derived from Paeonia, which exhibits anticancer properties. MicroRNA16 (miR16) is upregulated in CD133- cells, but downregulated in CD133+ cells from glioma tissue. Matrix metalloproteinase9 (MMP9) expression in glioma tissue samples is significantly higher than that in healthy brain tissue samples. Therefore, miR16 and MMP9 expression may be associated with glioma pathogenesis. In the present study, the effects of paeoniflorin on glioma were analyzed. U87 cells were treated with paeoniflorin at 0, 5, 10 and 20 µΜ concentrations. The results suggested that paeoniflorin inhibited U87 cell proliferation and accelerated cell apoptosis. In the present study paeoniflorin treatment increased miR16 expression and reduced MMP9 protein expression in U87 cells. Additionally, the results of the present study suggested that miR16 may regulate MMP9 expression in miR16transfected U87 cells. Furthermore, antimiR16 antibodies were used in order to investigate the apoptotic effects of paeoniflorin on U87 cells. The results demonstrated that paeoniflorin inhibits proliferation and induces apoptosis of human glial cells, via miR16 upregulation and MMP9 downregulation.
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Document Type: Research Article

Affiliations: 1: Department of Neurosurgery, 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China 2: Academic Affairs Office, Dalian Medical University, Dalian, Liaoning 116044, P.R. China 3: Department of Pharmacy, 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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