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MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinaseĀ 5 expression

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Glioblastoma is the most common primary malignancy of the adult central nervous system and is associated with a markedly poor prognosis. Elucidating the pathogenesis and molecular changes will assist in further understanding the pathogenesis and progression of the disease and offer novel targets for therapies. The present study demonstrated that the expression level of GK5 was lower in highgrade glioblastoma tissues compared with lowgrade ones and it can promote proliferation in glioblastoma cells. The regulatory mechanism of GK5 in glioblastoma were also investigated. It was revealed that GK5 is a target of miR135b in U87MG glioblastoma cells. Controry to GK5, the expression of miR135b is upregulated in glioblastoma and its expression is positively associated with the grade of the disease. Finally, it was demonstrated that miR135b promoted the proliferation of U87MG cells. Therefore, miR135b may function as an oncogene by inhibiting GK5 in glioblastoma.
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Document Type: Research Article

Affiliations: 1: Department of Neurosurgery, The Second Artillery General Hospital of The People's Liberation Army, Beijing 100088, P.R. China 2: Department of General Surgery, The Second Artillery General Hospital of The People's Liberation Army, Beijing 100088, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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