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Suppression of microRNA-18a expression inhibits invasion and promotes apoptosis of human trophoblast cells by targeting the estrogen receptor α gene

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The purpose of the present study was to gain further understanding of the function of microRNA-18a (miR-18a) expression in the JEG3 human trophoblast cell line. JEG3 cells were transfected with premiR18a mimics or miR18a inhibitors. The effects of miR18a on trophoblast cell invasion and apoptosis, and on the expression of estrogen receptor¬†α (ESRα) were analyzed using a Transwell invasion assay, flow cytometry, reverse transcriptionpolymerase chain reaction, western blot analysis and a luciferase assay. The results of the present study suggested that miR18a expression suppression led to a decrease in JEG3 cell invasion and an increase in JEG3 cell apoptosis, by inducing ESRα expression. The present study provides evidence for the involvement of miR18a in the pathogenesis of pre-eclamptic pregnancies.
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Document Type: Research Article

Affiliations: 1: Department of Obstetrics and Gynecology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shanxi 710038, P.R. China 2: Department of Obstetrics and Gynecology, Affiliated Hospital of Xi'an Medical University, Xi'an, Shanxi 710077, P.R. China 3: Department of Orthopedics, Hainan Branch of PLA General Hospital, Sanya, Hainan 572013, P.R. China 4: Department of Obstetrics and Gynecology, General Hospital of Chinese People's Liberation Army, Beijing 100853, P.R. China 5: Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shanxi 710038, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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