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Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells

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Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the balding population. In the present study, troxerutin, a flavonoid derivative of rutin, was demonstrated to have a protective effect against H2O2mediated cellular damage in human DP (HDP) cells. Biochemical assays revealed that pretreatment with troxerutin exerted a protective effect against H2O2induced loss of cell viability and H2O2induced cell death. Further experiments confirmed that troxerutin inhibited the H2O2induced production of ROS and upregulation of senescenceassociated βgalactosidase activity. Using microRNA (miRNA) microarrays, the present study identified 24┬ámiRNAs, which were differentially expressed in the troxerutinpretreated, H2O2treated HDP cells. Subsequent prediction using bioinformatics analysis revealed that the altered miRNAs were functionally involved in several cell signaling pathways, including the mitogenactivated protein kinase and WNT pathways. Overall, these results indicated that ROSmediated cellular damage was inhibited by troxerutin and suggested that the use of troxerutin may be an effective approach in the treatment of alopecia.
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Document Type: Research Article

Affiliations: 1: MolecularTargeted Drug Research Center and Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143701, Republic of Korea 2: Coreana Cosmetics Co., Ltd., Cheonan, Chungcheong 330882, Republic of Korea

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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