Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein
Mesenchymal stem cell (MSC)-based regenerative therapy is currently regarded as a novel approach with which to repair damaged tissues. However, the efficiency of MSC transplantation is limited due to the low survival rate of engrafted MSCs. Lipopolysaccharide (LPS) production is increased in numerous diseases and serves an essential function in the regulation of apoptosis in a variety of cell types. Previous studies have indicated that lowdose LPS pretreatment contributes to cytoprotection. In the current study, LPS was demonstrated to induce apoptosis in human umbilical cord mesenchymal stem cells (hUCMSCs) via the activation of caspase, in a dosedependent manner. Lowdose LPS pretreatment may protect hUCMSCs against apoptosis induced by highdose LPS, by upregulating the expression of cellular FADDlike IL1βconverting enzymeinhibitory protein (cFLIP). The results of the present study indicate that pretreatment with an appropriate concentration of LPS may alleviate high-dose LPS-induced apoptosis.
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Document Type: Research Article
Affiliations: Department of Burns and Plastic Surgery, The First Affiliated Hospital of PLA General Hospital, Beijing 100048, P.R. China
Publication date: August 1, 2015
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