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Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

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Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygeninsensitive β subunits, and are key regulators of gene expression during hypoxia in normal and solid tumor tissues. Three members of the HIF family, HIF1α, HIF2α, and HIF3α, are currently known. HIF3α differs from HIF1α and HIF2α in protein structure and regulation of gene expression. For a long time, HIF3α was considered as a negative mediator of HIFregulated genes. HIF3 has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF1α and HIF2α in binding to transcriptional elements in target genes during hypoxia. Previously, certain target genes of HIF3α have been identified, confirming the role of HIF3α as a transcription factor. In this review, the protein structure, gene regulation and biological function of HIF-3 are discussed based on the literature.
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Document Type: Research Article

Affiliations: 1: Department of General Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China 2: Department of Medicine and Division of Digestion Disease, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430077, P.R. China 3: Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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