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Aberrant methylation of the GCK gene body is associated with the risk of essential hypertension

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Essential hypertension (EH) is commonly accompanied by a dysfunction of glucose metabolism. Glucokinase (GCK) is a key enzyme involved in glucose metabolism. The aim of the present study was to investigate whether GCK genebody methylation contributed to the risk of EH. A total of 47 patients with EH and 47 agematched controls were recruited for methylation research in the current study. GCK genebody methylation was measured using bisulphite pyrosequencing technology. DNA methylation levels were closely correlated among CpG1, CpG2 and CpG3 (r>0.70; P<0.001), in contrast with a weaker correlation between CpG4 and the preceding three CpGs (r<0.3 or r=1; P>0.05). Significantly lower CpG13 methylation (cases vs. controls, 49.13±5.72 vs. 53.49±7.53%; adjusted P=0.006) and significantly higher CpG4 methylation (cases vs. controls, 46.34±6.48 vs. 34.74±12.73%; adjusted P=0.002) were observed in patients with EH. The present study indicated that aberrant methylation of the GCK gene body was significantly associated with the risk of EH in the population assessed. The discrepancies between CpG13 and CpG4 methylation may suggest distinct roles for each of them in the determination of the risk of EH.
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Document Type: Research Article

Affiliations: 1: Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China 2: Department of General Medicine, Ningbo Baizhang Street Community Health Service Center, Ningbo, Zhejiang 315211, P.R. China 3: Clinical Laboratory, The Seventh Hospital of Ningbo, Ningbo, Zhejiang 315211, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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