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MicroRNA-9 suppresses the sensitivity of CNE2 cells to ultraviolet radiation

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MicroRNA (miR)-9 has been demonstrated to regulate the radiosensitivity of tumor cells. In the present study, the mechanism by which miR9 modulates the sensitivity of nasopharyngeal carcinoma (NPC) cells to ultraviolet (UV) radiation was investigated. The results demonstrated that exposure of NPC cells to UV light resulted in a significant increase in the expression of miR9, and that CNE2 cells overexpressing miR9 exhibited reduced levels of DNA damage and increased levels of total glutathione upon UV exposure. Accordingly, the inhibition of the expression of miR9 promoted UVinduced DNA damage and apoptosis. Although miR9 inhibited the expression of Ecadherin in the CNE2 cells and increased their resistance to UV radiation, the use of small interfering RNA to inhibit the expression of Ecadherin was not sufficient to decrease the radiosensitivity of the NPC cells. These data demonstrated that miR9 did not modulate the sensitivity of the CNE2 cells to UV radiation through Ecadherin, but suggested that miR9 regulated radiosensitivity through its effects on glutathione. These findings suggest that miR9 may be a potential target for modulating the radiosensitivity of NPC cells.
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Document Type: Research Article

Affiliations: 1: Department of Otorhinolaryngology, The First Affiliated Hospital and Otorhinolaryngology Institute, Sun YatSen University, Guangzhou, Guangdong 510080, P.R. China 2: Department of Otolaryngology, First People's Hospital, Foshan, Guangdong 528000, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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