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MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1

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MicroRNAs (miRs) are a class of small non-coding RNAs that are involved in the regulation of gene expression, and in cancer development and progression. In the present study, miR320 expression was found to be significantly reduced in glioma tissue in comparison with that in adjacent healthy tissues. In the present study, in vitro analyses demonstrated that overexpression of miR320 inhibited cell proliferation and metastasis, while antisense miR320 oligonucleotides enhanced cell proliferation and migration in U251 and SHG44 glioma cell lines, compared with that in negative control cells. Protein expression of E2F1, a cellcycle regulator, was negatively regulated by miR320. Therefore, the present study provides novel insights into the association between miR-320 and glioma development.
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Document Type: Research Article

Affiliations: 1: Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China 2: Department of Neurology, Shanghai Pudong Hospital, Fudan University, Pudong, Shanghai 201399, P.R. China 3: Department of Neurosurgery, Tongji Hospital, Tongji University, Shanghai 200065, P.R. China 4: Department of Neurosurgery, Longhua Hospital Affiliated Shanghai Traditional Chinese Medical University, Shanghai 200032, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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