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Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice

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Schisandra chinensis Turcz. fruit is widely used to treat skin diseases. The aim of this study was to determine the anti-inflammatory effects of the methanol extract of S. chinensis (MESC) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) in mice. The effects of MESC on ear thickness and weight, histopathological changes, immune cell filtration and cytokine production were investigated in DNFB-induced CD mice. Topical application of MESC effectively inhibited ear swelling (30 or 300 µg on the left ear, P<0.001; 30 µg on the right ear, P<0.001). MESC also inhibited hyperplasia, spongiosis (100 µg/ear, P<0.05 and 300 µg/ear, P<0.001, respectively) and immune cell infiltration (100 µg/ear, P<0.05; 300 µg/ear, P<0.001) induced by DNFB. In addition, MESC suppressed increases in tumor necrosis factor (TNF)α levels (100 or 300 µg/ear, P<0.05), interferon (INF)γ (30 µg/ear, P<0.05; 100 µg/ear, P<0.01; 300 µg/ear, P<0.001), interleukin (IL)6 (300 µg/ear, P<0.05) and monocyte chemoattractant protein (MCP)1 (30 µg/ear, P<0.05; 100 µg/ear, P<0.01; 300 µg/ear, P<0.001). These results suggest that the antiinflammatory effects of MESC are mediated by the reduced production of TNFα, IFNγ, IL6 and MCP1, and that MESC has potential use for the treatment of inflammatory skin diseases.
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Document Type: Research Article

Affiliations: 1: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626870, Republic of Korea 2: Division of Pharmacology, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626870, Republic of Korea 3: Division of Applied Medicine, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626870, Republic of Korea 4: Department of Herbology, Wonkwang University College of Medicine, Iksan, North Jeolla 570749, Republic of Korea 5: Department of Oral Pathology, Pusan National University School of Dentistry, Yangsan, Gyeongsangnam-do 626870, Republic of Korea

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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