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Association between the expression of T-cadherin and vascular endothelial growth factor and the prognosis of patients with gastric cancer

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T-cadherin has been identified as a tumor-suppressor gene in several types of cancer. The present study aimed to investigate the association of the expression of T-cadherin with angiogenesis, and to evaluate its prognostic value for patients with primary gastric cancer. Gastric cancer tissues and matched adjacent tissues from 166 patients receiving surgical resection were included in the present study. The expression of Tcadherin was detected using immunohistochemistry, western blotting and reverse transcriptionquantitative polymerase chain reaction. The expression of vascular epidermal growth factor (VEGF) was detected using immunohistochemistry, and its association with the expression of Tcadherin was analyzed. In addition, the association between the expression of Tcadherin and clinicopathological features were analyzed. The mRNA and protein expression levels of Tcadherin were significantly lower in the gastric cancer tissue compared with the corresponding adjacent normal tissue (P<0.05). The expression of VEGF was not associated with the expression of Tcadherin in the gastric cancer tissue. The decreased protein expression of Tcadherin correlated with smoking, larger tumor size (diameter, >4 cm), lymph node metastasis and a higher tumorlymph nodemetastasis stage (P<0.05 or P<0.01). However, the expression of Tcadherin was not correlated with gender, age, alcohol intake, Helecobacter pylori infection or differentiation (P>0.05). The multivariate analysis demonstrated that the expression of Tcadherin was an independent prognostic factor for the overall survival rate of patients with gastric cancer. This data suggested that the downregulation of Tcadherin may contribute to gastric cancer progression, representing a useful biomarker for predicting the biological behavior and prognosis of gastric cancer. However, no significant association was observed between the expression of VEGF and T-cadherin.
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Document Type: Research Article

Affiliations: 1: Department of Gastroenterology, Xi'an No. 1 Hospital, Xi'an, Shaanxi 710002, P.R. China 2: Department of Gastroenterology, The Second Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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