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Calciumsensing receptor is involved in the pathogenesis of fat emulsioninduced insulin resistance in rats

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A highfat diet not only leads to obesity, but also leads to a predisposition towards insulin resistance (IR), which is characterized by hyperinsulinemia and reduced glucose tolerance. However, the etiology of IR remains to be fully elucidated. The present study investigated whether calciumsensing receptor (CaSR) is involved in the development of IR in rats fed a highfat diet. IR was induced in the rats by feeding with a fat emulsion via gavage for 2, 4, 6 or 8 weeks. Reverse transcriptionquantitative polymerase chain reaction (RTqPCR) and western blot analysis were performed to investigate whether CaSRassociated proteins were affected. The gavage of fat emulsion for 8 weeks induced a notable decline in the insulin sensitivity index (ISI) between 4.98 and 5.60. With 6 weeks of gavage, a significant difference in the ISI was observed between the IR and control groups. The results of the RTqPCR and western blot analysis demonstrated that phosphatidylinositol 3kinase/Akt pathway, which is a pathway closely associated with the CaSR signaling pathway, was significantly inhibited in the rats with IR. The results of the present study provided evidence that CaSR is associated with the development of IR in rats fed a highfat diet and suggested that CaSR may be important in the pathogenesis of diabetes.
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Document Type: Research Article

Affiliations: Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China

Publication date: August 1, 2015

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  • Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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