Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms
The aim of the present study was to investigate the association of neonatal necrotizing enterocolitis (NEC) with myeloid differentiation(MD2) and GM2 activator protein (GM2A) genetic polymorphisms. Gene resequencing of the MD2 and GM2A gene exons was performed on 42 neonates,
diagnosed with NEC (NEC group), as well as in the rs11465996 locus, located in the MD2 gene promoter region. The aim was to detect the genetic polymorphisms present in the neonates with NEC and compare the functional polymorphic loci with 83 neonates without NEC (control group), who had
been born during the same period. A polymorphic locus with abnormal frequency was detected in the exon region of the MD2 gene. In the NEC group, the frequency of genotypes carrying the low frequency allele (G) in the rs11465996 locus (MD2 promoter region) was significantly higher compared
with the control group (χ2=4.388, P=0.036). Furthermore, the frequencies of genotypes carrying the low frequency A and C alleles in the rs1048719 (GM2A gene exon 1) and rs2075783 loci (GM2A intron), respectively, were significantly higher in the NEC group compared with the
control group (χ2=4.316, P=0.038; and χ2=13.717, P=0.000, respectively). In addition, the rs11465996 polymorphism in the MD2 gene promoter region was found to be associated with the severity of NEC. Furthermore, the rs2075783 polymorphism in the GM2A gene exon 1 and the rs1048719
polymorphism in the intron region of this gene, were associated with the occurrence of NEC. The present study demonstrated that gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of NEC; however, further indepth exploration is required to clarify the associations
between genetic predispositions to polymorphisms, and NEC.
Document Type: Research Article
Affiliations: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China
Publication date: 01 January 2015
- Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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