Skip to main content
padlock icon - secure page this page is secure

β-catenin mutation is correlated with a favorable prognosis in patients with hepatocellular carcinoma

Buy Article:

$42.00 + tax (Refund Policy)

The β-catenin gene is frequently mutated in patients with hepatocellular carcinoma (HCC) and has long been thought to be one of the major oncogenes involved in the hepatocarcinogenesis. The prognostic role of βcatenin mutation in HCC remains unclear. To address this issue, a search for relevant studies was performed in the PubMed, Embase and Web of Science databases. The pooled effect was calculated from the available data to evaluate the correlation of βcatenin mutation with overall survival rate and tumor clinicopathological features in patients with HCC. The pooled odds ratio (OR) was calculated using the MantelHaenszel model for fixed effects. Three studies met the inclusion criteria. A total of 618 cases were included, and βcatenin mutation was identified in 104 of them. The metaanalysis revealed that the presence of βcatenin mutation (n=104), compared with the control group (n=514), was correlated with a longer overall survival rate [OR, 0.33; 95% confidence interval (CI), 0.210.53; P<0.00001] in patients with HCC. No significant heterogeneity was found among the eligible studies (I2=0%; P=0.72). βcatenin mutation was correlated with a relatively lower rate of hepatitis B virus infection (OR, 0.36; 95% CI, 0.210.61; P=0.0002), improved tumor differentiation (OR, 0.32; 95% CI, 0.190.56; P<0.0001) and a lower tumornodemetastasis stage (I+II) (OR, 0.23; 95% CI, 0.140.38; P<0.00001). These findings suggest that βcatenin mutation may predict a favorable prognosis in patients with HCC.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China 2: Institute of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China

Publication date: January 1, 2015

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more