miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma
Newly discovered intrinsic regulators, the miRNAs regulate gene expression by binding to the 3'-untranslated regions of the genome. Accumulating studies have indicated that miRNAs are aberrantly expressed in various human cancers. We found that miRNA-1207-5p (miR1207-5p) was markedly downregulated in esophageal carcinoma (EC) tissues, and was correlated with EC differentiation, pathological stage and lymph node metastasis. Rates of apoptosis were increased and cell invasion ability was decreased in EC9706 and EC-1 cells transfected with a miR1207-5p mimic. Stomatin-like protein 2 (STOML-2) was predicted to be a potential target of miR1207-5p by bioinformatics analysis and this was confirmed by luciferase assay and western blotting. Our study showed that STOML-2 was negatively regulated by miR1207-5p. Furthermore, overexpression of STOML-2 abolished the miR1207-5p anti-invasion function. Based on these results, we proposed that miR1207-5p might act as a potential therapeutic target in the treatment of EC.
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Document Type: Research Article
Affiliations: 1: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China 2: Tumor Hospital of Linzhou City, Linzhou, Henan 456500, P.R. China
Publication date: January 1, 2015
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- The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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