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Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review)

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Cells are tightly regulated by sophisticated systems. Among such systems, post-translational modification has been intensively studied, and the ubiquitin-proteasome system is one of the best-known proteolytic mechanisms for the timely destruction of regulatory proteins. As progress has been made in research on the ubiquitin-proteasome system, our understanding of fundamental regulatory circuits, such as the cell cycle and circadian rhythms, has progressed. Here, we focused on the SKP1-CUL1-F-box protein of E3 ubiquitin ligase, especially the F-box and additional characteristic domain-containing proteins, as adaptors for regulatory proteins. Accumulating evidence suggests that the F-box and additional characteristic domain-containing proteins are involved in a wide variety of cellular processes and pathogenesis. This raises the possibility that F-box and additional characteristic domain-containing proteins could be used as biomarkers for certain diseases.
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Document Type: Research Article

Affiliations: Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan

Publication date: November 1, 2010

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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