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Single-chain antibodies: A therapeutic modality for cancer gene therapy (Review)

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Gene therapy has rapidly evolved into a field that is treating not only inborn errors of metabolism, but other diseases associated with poor outcomes such as malignancy, where transient gene expression can be therapeutic. Cancer gene therapy is a novel form of treatment that exploits differences at the molecular level between normal and malignant cells. Current gene therapy approaches that are being evaluated include the use of replication competent viruses, mutation compensation strategies, improved targeting with tumor specific promoters, and the utilization of enhanced infectivity viruses. An additional aspect of gene therapy that has gained increased interest in the last several years is the utilization of single-chain antibodies (scFv). Specifically, scFv have been utilized to target molecular processes associated with carcinogenesis, as well as to improve gene transfer efficiency. We will limit our discussion to the role of scFv in targeting molecular processes associated with carcinogenesis.
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Document Type: Research Article

Affiliations: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA

Publication date: April 1, 2004

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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