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DLX-7 homeobox gene regulates c-myc and GATA-1 gene expression in different stages respectively.

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Homeobox genes code for transcription factors with a highly conserved DNA binding motif, but their target genes are largely unknown. We have shown that inhibition of the DLX-7 homeobox gene by an antisense oligonucleotide decreased the expression of c-myc and GATA-1 genes. Nuclear run-on assay revealed decreased transcriptional activity of c-myc but not of GATA-1 after DLX-7 antisense treatment. Actinomycin D chase experiments demonstrated that GATA-1 mRNA became unstable as a result of DLX-7 inhibition, whereas c-myc mRNA stability was unaffected. These results suggest that DLX-7 may regulate c-myc and GATA-1 genes at transcriptional and post-transcriptional levels.
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Document Type: Research Article

Affiliations: First Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan.

Publication date: January 1, 1999

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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