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Antiproliferative effect of synthetic resveratrol on human breast epithelial cells.

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Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a phytoalexin, is a constituent of the human diet that has been shown to inhibit cellular processes associated with tumor initiation, promotion and progression. In this study, we examined the effect of synthetic resveratrol on the proliferative capacity of immortal and neoplastic human breast epithelial cells in culture. MCF-7, an estrogen receptor-positive breast cancer cell line, MCF-10F, an immortal estrogen receptor-negative breast epithelial cell line, and MDA-MB-231, a malignant estrogen receptor-negative breast epithelial cell line, were treated with 5, 10, 20 or 40 microg/ml resveratrol, and their proliferative activities were determined with the WST-1 colorimetric assay after periods of time ranging from 24 to 144 h of treatment. Our results showed that this phytoalexin inhibited the proliferation of human breast epithelial cells in a dose- and time-dependent manner. Treatment of cells with resveratrol reduced the number of viable cells and prevented the exponential growth of the three cell lines examined. These observations indicate that resveratrol has a direct antiproliferative effect on human breast epithelial cells that is independent of the estrogen receptor status of the cells. Thus, this dietary compound is a potential chemopreventive agent for both hormone responsive and non-responsive breast cancers.
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Document Type: Research Article

Affiliations: Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Publication date: January 1, 1998

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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