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The role of fibroblast growth factor (FGF) in neoplasms induced by MoMuSV-349

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Previous results from our laboratory have demonstrated that intraperitoneal inoculation of newborn BALB/c mice with MoMuSV-349 virus induced multiorgan disseminated angiomatous tumors. Changes in histological pattern, from sarcomatous to angiosarcomatous, stimulated our interest in investigating the possible role of angiogenic growth factors released by the spindled (sarcomatous) cells in angiosarcoma development in this model. Cell lines were obtained from various tumors and assayed for production of acidic (a) and basic (b) fibroblast growth factors (FGFs). All tumor cell lines released detectable amounts of growth factor(s) into the cultured media that induced proliferation of endothelial cells and mitogenesis of mouse fibroblasts. This growth factor(s) bound to heparin Sepharose (HS) beads and its effects on cell proliferation were partially blocked by a neutralizing bFGF antibody. Proteins released by tumor cells into the conditioned medium were detected by bFGF antibodies on Western blots. In addition, proteins that reacted with both bFGF and aFGF antibodies were detected in various conditioned media by ELISA. This protein(s) from the FGF family detected in the conditioned media from various tumor cell lines might be responsible for the angiomatous proliferation observed in the late (angiosarcomatous) stage of MoMuSV-induced tumors.
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Document Type: Research Article

Affiliations: TEXAS A&M UNIV,COLL MED,DEPT MED PHYSIOL,COLLEGE STN,TX 77843. TEXAS A&M UNIV,COLL MED,DIV CARDIOL,COLLEGE STN,TX 77843. OKLAHOMA STATE UNIV,COLL VET MED,DEPT VET PATHOL,STILLWATER,OK 74078.

Publication date: January 1, 1997

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  • The International Journal of Oncology provides an international forum for the publication of the latest, cutting-edge research in the broad area of oncology and cancer treatment. The journal accepts original high quality works and reviews on all aspects of oncology research including carcinogenesis, metastasis, epidemiology, chemotherapy and viral oncology. Through fair and efficient peer review, the journal is dedicated to publishing top tier research in the field, offering authors rapid publication as well as high standards of copy-editing and production. The International Journal of Oncology is published on a monthly basis in both print and early online.
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